Anti-Inflammatory Functions of Protein C Require RAGE and ICAM-1 in a Stimulus-Dependent Manner

• Main Authors: Natascha Braach (Author), Kirsten Buschmann (Author), Johanna Pflaum (Author), Hannes Hudalla (Author), Lutz Koch (Author), Eduard Ryschich (Author), Johannes Poeschl (Author), David Frommhold (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2014-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

By binding β2-integrins both ICAM-1 and the receptor for advanced glycation end products (RAGE) mediate leukocyte recruitment in a stimulus-dependent manner. Using different inflammatory mouse models we investigated how RAGE and ICAM-1 are involved in anti-inflammatory functions of protein C (PC; Ce...