Advances in the use of PARP inhibitor therapy for breast cancer

Poly-ADP-ribose polymerase 1 (PARP-1) and PARP-2 are DNA damage sensors that are most active during S-phase of the cell cycle and that have wider-reaching roles in DNA repair than originally described. BRCA1 and BRCA2 (Breast Cancer) proteins are involved in homologous recombination repair (HRR), wh...

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Main Authors: Kelly E McCann (Author), Sara A Hurvitz (Author)
Formato: Libro
Publicado: BioExcel Publishing Ltd, 2018-08-01T00:00:00Z.
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