Advances in the use of PARP inhibitor therapy for breast cancer

• Κύριοι συγγραφείς: Kelly E McCann (Συγγραφέας), Sara A Hurvitz (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: BioExcel Publishing Ltd, 2018-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Poly-ADP-ribose polymerase 1 (PARP-1) and PARP-2 are DNA damage sensors that are most active during S-phase of the cell cycle and that have wider-reaching roles in DNA repair than originally described. BRCA1 and BRCA2 (Breast Cancer) proteins are involved in homologous recombination repair (HRR), wh...