Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation

• Main Authors: Fabiola Paciello (Author), Anna Pisani (Author), Rolando Rolesi (Author), Vincent Escarrat (Author), Jacopo Galli (Author), Gaetano Paludetti (Author), Claudio Grassi (Author), Diana Troiani (Author), Anna Rita Fetoni (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cross-talk between oxidative stress and inflammation seems to play a key role in noise-induced hearing loss. Several studies have addressed the role of PPAR receptors in mediating antioxidant and anti-inflammatory effects and, although its protective activity has been demonstrated in several tis...