Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer

• Auteurs principaux: Yiqin He (Auteur), Xiangyang Le (Auteur), Gaoyun Hu (Auteur), Qianbin Li (Auteur), Zhuo Chen (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Cdc20 is a promising drug target that plays an important role in the mid-anaphase process of cellular mitosis, and Apcin is the only reported core structure of the Cdc20-specific inhibitor. Some potent Apcin derivatives were obtained in our previous research, and a structure-activity relationship wa...