Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer

Cdc20 is a promising drug target that plays an important role in the mid-anaphase process of cellular mitosis, and Apcin is the only reported core structure of the Cdc20-specific inhibitor. Some potent Apcin derivatives were obtained in our previous research, and a structure-activity relationship wa...

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Main Authors: Yiqin He (Author), Xiangyang Le (Author), Gaoyun Hu (Author), Qianbin Li (Author), Zhuo Chen (Author)
Format: Book
Published: MDPI AG, 2023-02-01T00:00:00Z.
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3rd Floor Main Library

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