Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

• Main Authors: Mei-Ling Han (Author), Xiaofen Liu (Author), Tony Velkov (Author), Yu-Wei Lin (Author), Yan Zhu (Author), Darren J. Creek (Author), Christopher K. Barlow (Author), Heidi H. Yu (Author), Zhihui Zhou (Author), Jing Zhang (Author), Jian Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies. Polymyxins in combination with β-lactams have shown remarkable syne...