Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

• Автори: Mei-Ling Han (Автор), Xiaofen Liu (Автор), Tony Velkov (Автор), Yu-Wei Lin (Автор), Yan Zhu (Автор), Darren J. Creek (Автор), Christopher K. Barlow (Автор), Heidi H. Yu (Автор), Zhihui Zhou (Автор), Jing Zhang (Автор), Jian Li (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies. Polymyxins in combination with β-lactams have shown remarkable syne...