Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies

• Príomhchruthaitheoirí: Bo Zhao (Údar), Joy Yoon (Údar), Bojie Zhang (Údar), Youmi Moon (Údar), Yue Fu (Údar), Yinyin Li (Údar), Yunlong Zhao (Údar), Hui Xiao (Údar), Ning Li (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). It is imperative to fully understand the effects of methionine oxidation because these modifications can affect t...