Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies

• Main Authors: Bo Zhao (Author), Joy Yoon (Author), Bojie Zhang (Author), Youmi Moon (Author), Yue Fu (Author), Yinyin Li (Author), Yunlong Zhao (Author), Hui Xiao (Author), Ning Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). It is imperative to fully understand the effects of methionine oxidation because these modifications can affect t...