Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/β-Lactoglobulin Adduct

• Main Authors: Daria Maria Monti (Author), Domenico Loreto (Author), Ilaria Iacobucci (Author), Giarita Ferraro (Author), Alessandro Pratesi (Author), Luigi D'Elia (Author), Maria Monti (Author), Antonello Merlino (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-03-01T00:00:00Z.
• Fag: article
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β-lactoglobulin is the major component of whey. Here, the adduct formed upon the reaction of the protein with oxaliplatin (OXA) has been prepared, structurally characterized by X-ray crystallography and electrospray ionization-mass spectrometry, and evaluated as a cytotoxic agent. The data demonstra...