Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/β-Lactoglobulin Adduct

• 主要な著者: Daria Maria Monti (著者), Domenico Loreto (著者), Ilaria Iacobucci (著者), Giarita Ferraro (著者), Alessandro Pratesi (著者), Luigi D'Elia (著者), Maria Monti (著者), Antonello Merlino (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

β-lactoglobulin is the major component of whey. Here, the adduct formed upon the reaction of the protein with oxaliplatin (OXA) has been prepared, structurally characterized by X-ray crystallography and electrospray ionization-mass spectrometry, and evaluated as a cytotoxic agent. The data demonstra...