PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

• Main Authors: Peiyi Zhang (Author), Xuan Zhang (Author), Xingui Liu (Author), Sajid Khan (Author), Daohong Zhou (Author), Guangrong Zheng (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BCL-XL is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-XL has also been identified as a key survival factor in senescent cells. Accumulation of senescent cells has been indicated as a...