Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method

• Main Authors: Fang Li (Author), Linsen Li (Author), Shaoning Wang (Author), Yan Yang (Author), Jia Li (Author), Dongchun Liu (Author), Sijie Zhang (Author), Siling Wang (Author), Hui Xu (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this work is to construct a nanosuspension drug delivery system of probucol, a BCS II drug, in order to improve its dissolution and oral bioavailability. The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticl...