Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method

• Үндсэн зохиолчид: Fang Li (Зохиогч), Linsen Li (Зохиогч), Shaoning Wang (Зохиогч), Yan Yang (Зохиогч), Jia Li (Зохиогч), Dongchun Liu (Зохиогч), Sijie Zhang (Зохиогч), Siling Wang (Зохиогч), Hui Xu (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2019-11-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The objective of this work is to construct a nanosuspension drug delivery system of probucol, a BCS II drug, in order to improve its dissolution and oral bioavailability. The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticl...