Deciphering LAG-3: unveiling molecular mechanisms and clinical advancements

• Hauptverfasser: Alejandra Martínez-Pérez (Verfasst von), Rocío Granda-Díaz (Verfasst von), Candelaria Aguilar-García (Verfasst von), Christian Sordo-Bahamonde (Verfasst von), Segundo Gonzalez (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2024-10-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Treatment based on immune checkpoint blockade has revolutionized cancer therapy. Despite the remarkable success achieved and the preclinical development of multiple checkpoint inhibitors targeting other checkpoints, only antibodies targeting the PD-1/PD-L1 axis and CTLA-4 have been approved...