Deciphering LAG-3: unveiling molecular mechanisms and clinical advancements

• Autores principales: Alejandra Martínez-Pérez (Autor), Rocío Granda-Díaz (Autor), Candelaria Aguilar-García (Autor), Christian Sordo-Bahamonde (Autor), Segundo Gonzalez (Autor)
• Formato: Libro
• Publicado: BMC, 2024-10-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Treatment based on immune checkpoint blockade has revolutionized cancer therapy. Despite the remarkable success achieved and the preclinical development of multiple checkpoint inhibitors targeting other checkpoints, only antibodies targeting the PD-1/PD-L1 axis and CTLA-4 have been approved...