Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials

• Main Authors: Rossana Franzin (Author), Alessandra Stasi (Author), Elena Ranieri (Author), Giuseppe Stefano Netti (Author), Vincenzo Cantaluppi (Author), Loreto Gesualdo (Author), Giovanni Stallone (Author), Giuseppe Castellano (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to end-stage renal disease, requiring renal replacement therapy. Since the discovery of pivotal mechanisms of senescence such as cell cycle arrest, apoptosis inhibition...