Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB

• Main Authors: Kegang Linghu (Author), Wenqing Cui (Author), Taiqin Li (Author), Yueting Tuo (Author), Dasong Wang (Author), Huiqi Pan (Author), Tian Zhang (Author), Ligen Lin (Author), Hua Yu (Author), Xiaoxia Hu (Author), Haiyang Li (Author), Xiangchun Shen (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is an inflammatory disease accompanied by abnormal synovial microenvironment (SM). Sesquiterpene lactones (SLs) are the main anti-inflammatory ingredients of many traditional herbs utilized in RA treatment. α-Methylene-γ-butyrolactone (α-M-γ-B) is a core moiety that widely...