An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

• मुख्य लेखकों: Amanda Ackley (लेखक), Alexandra Lenox (लेखक), Kenneth Stapleton (लेखक), Stuart Knowling (लेखक), Tim Lu (लेखक), Kenny S Sabir (लेखक), Peter K Vogt (लेखक), Kevin V Morris (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2013-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Small noncoding antisense RNAs (sasRNAs) guide epigenetic silencing complexes to target loci in human cells and modulate gene transcription. When these targeted loci are situated within a promoter, long-term, stable epigenetic silencing of transcription can occur. Recent studies suggest that there e...