An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

• Main Authors: Amanda Ackley (Author), Alexandra Lenox (Author), Kenneth Stapleton (Author), Stuart Knowling (Author), Tim Lu (Author), Kenny S Sabir (Author), Peter K Vogt (Author), Kevin V Morris (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small noncoding antisense RNAs (sasRNAs) guide epigenetic silencing complexes to target loci in human cells and modulate gene transcription. When these targeted loci are situated within a promoter, long-term, stable epigenetic silencing of transcription can occur. Recent studies suggest that there e...