Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity

• Main Authors: Gema Marín-Royo (Author), Isabel Gallardo (Author), Ernesto Martínez-Martínez (Author), Beatriz Gutiérrez (Author), Raquel Jurado-López (Author), Natalia López-Andrés (Author), Josué Gutiérrez-Tenorio (Author), Eduardo Rial (Author), Marı́a Visitación Bartolomé (Author), María Luisa Nieto (Author), Victoria Cachofeiro (Author)
• Format: Book
• Published: The Company of Biologists, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is accompanied by metabolic alterations characterized by insulin resistance and cardiac lipotoxicity. Galectin-3 (Gal-3) induces cardiac inflammation and fibrosis in the context of obesity; however, its role in the metabolic consequences of obesity is not totally established. We have investi...