Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity

• Egile Nagusiak: Gema Marín-Royo (Egilea), Isabel Gallardo (Egilea), Ernesto Martínez-Martínez (Egilea), Beatriz Gutiérrez (Egilea), Raquel Jurado-López (Egilea), Natalia López-Andrés (Egilea), Josué Gutiérrez-Tenorio (Egilea), Eduardo Rial (Egilea), Marı́a Visitación Bartolomé (Egilea), María Luisa Nieto (Egilea), Victoria Cachofeiro (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2018-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Obesity is accompanied by metabolic alterations characterized by insulin resistance and cardiac lipotoxicity. Galectin-3 (Gal-3) induces cardiac inflammation and fibrosis in the context of obesity; however, its role in the metabolic consequences of obesity is not totally established. We have investi...