Efficient Synthesis and Docking Analysis of Selective CDK9 Inhibitor NVP-2

• Những tác giả chính: Abdusaid Saidahmatov (Tác giả), Xue-Wu Liang (Tác giả), Yu-Qiang Shi (Tác giả), Xu Han (Tác giả), Hong Liu (Tác giả)
• Định dạng: Sách
• Được phát hành: Georg Thieme Verlag KG, 2021-06-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Abstract Graphical Abstract NVP-2 (1), a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), showed potent antitumor activity in preclinical studies. In this work, we designed and adopted a convergent synthetic route to efficiently synthesize NVP-2 (1). The key intermediate (7) was s...