Efficient Synthesis and Docking Analysis of Selective CDK9 Inhibitor NVP-2

• Autores principales: Abdusaid Saidahmatov (Autor), Xue-Wu Liang (Autor), Yu-Qiang Shi (Autor), Xu Han (Autor), Hong Liu (Autor)
• Formato: Libro
• Publicado: Georg Thieme Verlag KG, 2021-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Graphical Abstract NVP-2 (1), a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), showed potent antitumor activity in preclinical studies. In this work, we designed and adopted a convergent synthetic route to efficiently synthesize NVP-2 (1). The key intermediate (7) was s...