Exogenous 8-Hydroxydeoxyguanosine Attenuates PM_2.5-Induced Inflammation in Human Bronchial Epithelial Cells by Decreasing NLRP3 Inflammasome Activation

• Main Authors: Jihye Bang (Author), Kuk Hui Son (Author), Hye-Ryeon Heo (Author), Eunsook Park (Author), Hyun-Jeong Kwak (Author), Kyung-Ok Uhm (Author), Myung-Hee Chung (Author), Young-Youl Kim (Author), Hyun Joung Lim (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Particulate matter 2.5 (PM_2.5) induces lung injury by increasing the generation of reactive oxygen species (ROS) and inflammation. ROS aggravates NLRP3 inflammasome activation, which activates caspase-1, IL-1β, and IL-18 and induces pyroptosis; these factors propagate inflamma...