BRCA1 foci test as a predictive biomarker of olaparib response in ovarian cancer patient-derived xenograft models

• Автори: Federica Guffanti (Автор), Ilaria Mengoli (Автор), Maria Francesca Alvisi (Автор), Giulia Dellavedova (Автор), Raffaella Giavazzi (Автор), Robert Fruscio (Автор), Eliana Rulli (Автор), Giovanna Damia (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Standard therapy for high-grade ovarian carcinoma includes surgery followed by platinum-based chemotherapy and poly-ADP ribose polymerase inhibitors (PARPis). Deficiency in homologous recombination repair (HRD) characterizes almost half of high-grade ovarian carcinomas and is due to genetic and epig...