BRCA1 foci test as a predictive biomarker of olaparib response in ovarian cancer patient-derived xenograft models

• Main Authors: Federica Guffanti (Author), Ilaria Mengoli (Author), Maria Francesca Alvisi (Author), Giulia Dellavedova (Author), Raffaella Giavazzi (Author), Robert Fruscio (Author), Eliana Rulli (Author), Giovanna Damia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Standard therapy for high-grade ovarian carcinoma includes surgery followed by platinum-based chemotherapy and poly-ADP ribose polymerase inhibitors (PARPis). Deficiency in homologous recombination repair (HRD) characterizes almost half of high-grade ovarian carcinomas and is due to genetic and epig...