Integrin/TGF-β1 Inhibitor GLPG-0187 Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity

• Auteurs principaux: Kelsey E. Huntington (Auteur), Lindsey Carlsen (Auteur), Eui-Young So (Auteur), Matthias Piesche (Auteur), Olin Liang (Auteur), Wafik S. El-Deiry (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

As COVID-19 continues to pose major risk for vulnerable populations, including the elderly, immunocompromised, patients with cancer, and those with contraindications to vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects target cells via RGD-binding integrins, either inde...