Integrin/TGF-β1 Inhibitor GLPG-0187 Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity

• Váldodahkkit: Kelsey E. Huntington (Dahkki), Lindsey Carlsen (Dahkki), Eui-Young So (Dahkki), Matthias Piesche (Dahkki), Olin Liang (Dahkki), Wafik S. El-Deiry (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

As COVID-19 continues to pose major risk for vulnerable populations, including the elderly, immunocompromised, patients with cancer, and those with contraindications to vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects target cells via RGD-binding integrins, either inde...