2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D <sup>1</sup>H-<sup>13</sup>C ALSOFAST-HMQC NMR spectra with immunochemical ELISA-based analysis to evaluate their sensitivity in assessin...

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Main Authors: Francesca Cantini (Author), Emanuele Andreano (Author), Ida Paciello (Author), Veronica Ghini (Author), Francesco Berti (Author), Rino Rappuoli (Author), Lucia Banci (Author)
Format: Book
Published: MDPI AG, 2022-09-01T00:00:00Z.
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