2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

• Hoofdauteurs: Francesca Cantini (Auteur), Emanuele Andreano (Auteur), Ida Paciello (Auteur), Veronica Ghini (Auteur), Francesco Berti (Auteur), Rino Rappuoli (Auteur), Lucia Banci (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D ¹H-¹³C ALSOFAST-HMQC NMR spectra with immunochemical ELISA-based analysis to evaluate their sensitivity in assessin...