2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

• 主要な著者: Francesca Cantini (著者), Emanuele Andreano (著者), Ida Paciello (著者), Veronica Ghini (著者), Francesco Berti (著者), Rino Rappuoli (著者), Lucia Banci (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D ¹H-¹³C ALSOFAST-HMQC NMR spectra with immunochemical ELISA-based analysis to evaluate their sensitivity in assessin...