Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

• Үндсэн зохиолчид: Talia Nasr (Зохиогч), Andrea M. Holderbaum (Зохиогч), Praneet Chaturvedi (Зохиогч), Kunal Agarwal (Зохиогч), Jessica L. Kinney (Зохиогч), Keziah Daniels (Зохиогч), Stephen L. Trisno (Зохиогч), Vladimir Ustiyan (Зохиогч), John M. Shannon (Зохиогч), James M. Wells (Зохиогч), Debora Sinner (Зохиогч), Vladimir V. Kalinichenko (Зохиогч), Aaron M. Zorn (Зохиогч)
• Формат: Ном
• Хэвлэсэн: The Company of Biologists, 2021-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...