Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

• Main Authors: Talia Nasr (Author), Andrea M. Holderbaum (Author), Praneet Chaturvedi (Author), Kunal Agarwal (Author), Jessica L. Kinney (Author), Keziah Daniels (Author), Stephen L. Trisno (Author), Vladimir Ustiyan (Author), John M. Shannon (Author), James M. Wells (Author), Debora Sinner (Author), Vladimir V. Kalinichenko (Author), Aaron M. Zorn (Author)
• Format: Book
• Published: The Company of Biologists, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...