Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha

• Main Authors: Hualin Yan (Author), Hong Wang (Author), Xiaoxia Zhu (Author), Jianbo Huang (Author), Yifei Li (Author), Kaiyu Zhou (Author), Yimin Hua (Author), Feng Yan (Author), Da-Zhi Wang (Author), Yan Luo (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies have shown that miR-199a is upregulated in pressure-overload cardiac hypertrophy and that inhibition of miR-199a attenuates cardiac hypertrophy in vitro. However, the therapeutic rol...