Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha

• मुख्य लेखकों: Hualin Yan (लेखक), Hong Wang (लेखक), Xiaoxia Zhu (लेखक), Jianbo Huang (लेखक), Yifei Li (लेखक), Kaiyu Zhou (लेखक), Yimin Hua (लेखक), Feng Yan (लेखक), Da-Zhi Wang (लेखक), Yan Luo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies have shown that miR-199a is upregulated in pressure-overload cardiac hypertrophy and that inhibition of miR-199a attenuates cardiac hypertrophy in vitro. However, the therapeutic rol...