New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed comparable activities with doxorubicin against the Caco-...

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主要な著者: Eslam B. Elkaeed (著者), Mohammed S. Taghour (著者), Hazem A. Mahdy (著者), Wagdy M. Eldehna (著者), Nehal M. El-Deeb (著者), Ahmed M. Kenawy (著者), Bshra A. Alsfouk (著者), Mohammed A. Dahab (著者), Ahmed M. Metwaly (著者), Ibrahim H. Eissa (著者), Mohamed A. El-Zahabi (著者)
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出版事項: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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