New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

• Main Authors: Eslam B. Elkaeed (Author), Mohammed S. Taghour (Author), Hazem A. Mahdy (Author), Wagdy M. Eldehna (Author), Nehal M. El-Deeb (Author), Ahmed M. Kenawy (Author), Bshra A. Alsfouk (Author), Mohammed A. Dahab (Author), Ahmed M. Metwaly (Author), Ibrahim H. Eissa (Author), Mohamed A. El-Zahabi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed comparable activities with doxorubicin against the Caco-...