Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs

• Главные авторы: Sveva Grande (Автор), Alessandra Palma (Автор), Lucia Ricci-Vitiani (Автор), Anna Maria Luciani (Автор), Mariachiara Buccarelli (Автор), Mauro Biffoni (Автор), Agnese Molinari (Автор), Annarica Calcabrini (Автор), Emanuela D'Amore (Автор), Laura Guidoni (Автор), Roberto Pallini (Автор), Vincenza Viti (Автор), Antonella Rosi (Автор)
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• Опубликовано: Hindawi Limited, 2018-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Clustering of patient-derived glioma stem-like cells (GSCs) through unsupervised analysis of metabolites detected by magnetic resonance spectroscopy (MRS) evidenced three subgroups, namely clusters 1a and 1b, with high intergroup similarity and neural fingerprints, and cluster 2, with a metabolism t...