Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs

• Main Authors: Sveva Grande (Author), Alessandra Palma (Author), Lucia Ricci-Vitiani (Author), Anna Maria Luciani (Author), Mariachiara Buccarelli (Author), Mauro Biffoni (Author), Agnese Molinari (Author), Annarica Calcabrini (Author), Emanuela D'Amore (Author), Laura Guidoni (Author), Roberto Pallini (Author), Vincenza Viti (Author), Antonella Rosi (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clustering of patient-derived glioma stem-like cells (GSCs) through unsupervised analysis of metabolites detected by magnetic resonance spectroscopy (MRS) evidenced three subgroups, namely clusters 1a and 1b, with high intergroup similarity and neural fingerprints, and cluster 2, with a metabolism t...