Proto-oncogene mutations in middle ear cholesteatoma contribute to its pathogenesis

• Main Authors: Chisei Satoh (Author), Koh-ichiro Yoshiura (Author), Hiroyuki Mishima (Author), Haruo Yoshida (Author), Haruo Takahashi (Author), Yoshihiko Kumai (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chronic inflammation causes bone destruction in middle ear cholesteatomas (MECs). However, the causes of their neoplastic features remain unknown. The present study demonstrated for the first time that neoplastic features of MEC are based on proto-oncogene mutations. Results DNA...