Proto-oncogene mutations in middle ear cholesteatoma contribute to its pathogenesis

• Главные авторы: Chisei Satoh (Автор), Koh-ichiro Yoshiura (Автор), Hiroyuki Mishima (Автор), Haruo Yoshida (Автор), Haruo Takahashi (Автор), Yoshihiko Kumai (Автор)
• Формат: ‌
• Опубликовано: BMC, 2023-11-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Background Chronic inflammation causes bone destruction in middle ear cholesteatomas (MECs). However, the causes of their neoplastic features remain unknown. The present study demonstrated for the first time that neoplastic features of MEC are based on proto-oncogene mutations. Results DNA...