Influence of Rifampin‐Mediated Organic Anion‐Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan

• Asıl Yazarlar: Pierre‐Eric Juif (Yazar), Christine Voors‐Pette (Yazar), Mike Ufer (Yazar), Peter Dogterom (Yazar), Jasper Dingemanse (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2019-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Clazosentan is a selective endothelin A receptor antagonist in development for the prevention and treatment of vasospasm postsubarachnoid hemorrhage. It is a substrate of organic anion‐transporting polypeptide 1B1/1B3 based on preclinical data. This randomized, double‐blind, two‐period, cross‐over s...