Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells

• Main Authors: Yuchao Wu (Author), Yajuan He (Author), Fei Wang (Author), Naijuan Yao (Author), Yingren Zhao (Author), Zhen Tian (Author)
• פורמט: ספר
• יצא לאור: Hindawi Limited, 2022-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Background. Inflammation plays a critical role in the progression of acute-on-chronic liver failure (ACLF). Atg13 is a vital regulatory component of the ULK1 complex, which plays an essential role in the initiation of autophagy. Previously, hepatic stellate cells (HSCs) were considered to be noninfl...