PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

• Váldodahkkit: Danielle C. Bonfim (Dahkki), Rhayra B. Dias (Dahkki), Anneliese Fortuna-Costa (Dahkki), Leonardo Chicaybam (Dahkki), Daiana V. Lopes (Dahkki), Hélio S. Dutra (Dahkki), Radovan Borojevic (Dahkki), Martin Bonamino (Dahkki), Claudia Mermelstein (Dahkki), Maria Isabel D. Rossi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Hindawi Limited, 2016-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Bone marrow stromal cells (BMSCs) are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canon...