PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

• Main Authors: Danielle C. Bonfim (Author), Rhayra B. Dias (Author), Anneliese Fortuna-Costa (Author), Leonardo Chicaybam (Author), Daiana V. Lopes (Author), Hélio S. Dutra (Author), Radovan Borojevic (Author), Martin Bonamino (Author), Claudia Mermelstein (Author), Maria Isabel D. Rossi (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow stromal cells (BMSCs) are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canon...