PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

• Autors principals: Danielle C. Bonfim (Autor), Rhayra B. Dias (Autor), Anneliese Fortuna-Costa (Autor), Leonardo Chicaybam (Autor), Daiana V. Lopes (Autor), Hélio S. Dutra (Autor), Radovan Borojevic (Autor), Martin Bonamino (Autor), Claudia Mermelstein (Autor), Maria Isabel D. Rossi (Autor)
• Format: Llibre
• Publicat: Hindawi Limited, 2016-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Bone marrow stromal cells (BMSCs) are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canon...