PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

• Prif Awduron: Danielle C. Bonfim (Awdur), Rhayra B. Dias (Awdur), Anneliese Fortuna-Costa (Awdur), Leonardo Chicaybam (Awdur), Daiana V. Lopes (Awdur), Hélio S. Dutra (Awdur), Radovan Borojevic (Awdur), Martin Bonamino (Awdur), Claudia Mermelstein (Awdur), Maria Isabel D. Rossi (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2016-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Bone marrow stromal cells (BMSCs) are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canon...