The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

• Главные авторы: Irina V. Varizhuk (Автор), Vladimir B. Tsvetkov (Автор), Ilya Yu. Toropygin (Автор), Andrey A. Stomakhin (Автор), Natalia A. Kolganova (Автор), Sergei A. Surzhikov (Автор), Edward N. Timofeev (Автор)
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• Опубликовано: MDPI AG, 2023-02-01T00:00:00Z.
• Предметы: article
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Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification. Chemical modification or the conjugation of therapeutic oligonucleotides is required to increase the...