The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification. Chemical modification or the conjugation of therapeutic oligonucleotides is required to increase the...

Full description

Saved in:
Bibliographic Details
Main Authors: Irina V. Varizhuk (Author), Vladimir B. Tsvetkov (Author), Ilya Yu. Toropygin (Author), Andrey A. Stomakhin (Author), Natalia A. Kolganova (Author), Sergei A. Surzhikov (Author), Edward N. Timofeev (Author)
Format: Book
Published: MDPI AG, 2023-02-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items