The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

• मुख्य लेखकों: Irina V. Varizhuk (लेखक), Vladimir B. Tsvetkov (लेखक), Ilya Yu. Toropygin (लेखक), Andrey A. Stomakhin (लेखक), Natalia A. Kolganova (लेखक), Sergei A. Surzhikov (लेखक), Edward N. Timofeev (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification. Chemical modification or the conjugation of therapeutic oligonucleotides is required to increase the...