Investigation of the profile and kinetics of degradation of rivaroxaban using HPLC, TLC-densitometry and LC/MS/MS: Application to pre-formulation studies

• Główni autorzy: Mohamed A. Abdallah (Autor), Medhat A. Al-Ghobashy (Autor), Hayam M. Lotfy (Autor)
• Format: Książka
• Wydane: Faculty of Pharmacy, Cairo University, 2015-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Rivaroxaban (RIVA), an amide group-containing oral anticoagulant was subjected to stress conditions commonly required for the registration of pharmaceuticals: base and acid-catalyzed hydrolysis (0.1 M, 60 °C, 3-6 h), oxidation (10% H2O2, 24 h), photodegradation (300-800 nm, 24 h) and thermal decompo...