Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells

• मुख्य लेखकों: Akiko Yamamuro (लेखक), Takashi Kishino (लेखक), Yu Ohshima (लेखक), Yasuhiro Yoshioka (लेखक), Tomoki Kimura (लेखक), Atsushi Kasai (लेखक), Sadaaki Maeda (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2011-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress-induced apoptosis in human neuronal cell line SH-SY5Y. Tunicamycin, which is known to induce ER stress, activated both caspase-9 and caspase-4, and the activation of caspase-4 preceded that of caspase-9. Th...