Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells

• Main Authors: Akiko Yamamuro (Author), Takashi Kishino (Author), Yu Ohshima (Author), Yasuhiro Yoshioka (Author), Tomoki Kimura (Author), Atsushi Kasai (Author), Sadaaki Maeda (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress-induced apoptosis in human neuronal cell line SH-SY5Y. Tunicamycin, which is known to induce ER stress, activated both caspase-9 and caspase-4, and the activation of caspase-4 preceded that of caspase-9. Th...